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KMID : 0043320150380101746
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Archives of Pharmacal Research
2015 Volume.38 No. 10 p.1746 ~ p.1751
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Chemical constituents from the aerial parts of Melandrium firmum
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Zhang Chang Hao
Luo Jie
Li Tian
Cui Yong
Jin Mei
Yao Da Lei
Zheng Ming Shan
Lin Zhen Hua
Cui Jiong Mo
Li Gao
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Abstract
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Two new anthraquinones, melrubiellin C (1) and melrubiellin D (2), were isolated from the aerial parts of Melandrium firmum Rohrbach, together with eight known compounds (3?10). The structures of these compounds were elucidated using 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) experiments. All isolated compounds were tested for their cytotoxicity against NCI-H460, Hep G2, MKN-28 and A-549 cells. Of these 10 compounds, 1 and 2 exhibited moderate cytotoxicity with IC50 values ranging from 9.54 to 32.41 μM.
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KEYWORD
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Melandrium firmum, Caryophyllaceae, Anthraquinone dimmer, Cytotoxicity
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